Table 1.
Drug loads and loading efficiency of Felodipine and Furosemide in mesoporous silica Syloid XDP 3050 (surface area of 310 m2/g).
| % of Theoretical Surface Coverage | Felodipine-Syloid | Furosemide-Syloid | ||||||
|---|---|---|---|---|---|---|---|---|
| Theoretical Drug Load (%, g/g) | Actual Drug Load (%, g/g) | Normalised Actual Drug Load (×10−3 g/m2) | Loading Efficiency (%) | Theoretical Drug Load (%, g/g) | Actual Drug Load (%, g/g) | Normalised Actual Drug Load (×10−3 g/m2) | Loading Efficiency (%) | |
| 100% | 12.6 | 12.5 ± 0.3 | 0.403 ± 0.010 | 99.2 ± 2.4 | 10.8 | 11.0 ± 0.9 | 0.355 ± 0.029 | 101.9 ± 8.3 |
| 200% | 25.2 | 15.6 ± 0.2 | 0.503 ± 0.006 | 61.9 ± 0.8 | 21.6 | 16.6 ± 0.3 | 0.535 ± 0.010 * | 76.9 ± 1.4 |
| 300% | 37.8 | 21.6 ± 0.3 | 0.697 ± 0.010 * | 57.4 ± 0.8 | 32.4 | 23.9 ± 0.5 | 0.771 ± 0.016 | 73.8 ± 1.5 |
(*): Drug load at which a complete amorphisation was successfully obtained.