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. 2019 May 22;12(2):79. doi: 10.3390/ph12020079

Figure 5.

Figure 5

The role of MMP-8 in diabetic wound healing. (A) Structure of selective MMP-8 inhibitor. (B,C) Topical treatment with selective MMP-8 inhibitor (250 μg/wound/day) delays healing in diabetic mice; mean ± SD, n = 12, 6, and 6 on days 7, 10, and 14, respectively; * p < 0.05. (D,E) Topical treatment with exogenous recombinant MMP-8 (1 μg/wound/day) accelerates diabetic wound healing; mean ± SEM, n = 20, 9, and 9 mice on days 7, 10, and 14, respectively, for the vehicle group; n = 20, 10, and 10 mice on days 7, 10, and 14, respectively, for the MMP-8 group; * p < 0.05. Adapted from Gooyit et al. [67] and Gao et al. [86].