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Validation of the target MMP-9 in debridement tissue from human patients with diabetic foot ulcers (DFUs). Measurements of (A) active MMP-8 and (B) active MMP-9 in human DFUs stratified by the Wagner grade (WG) using the batimastat affinity resin coupled with proteomics; mean ± SEM: * p < 0.05, ** p < 0.01 by Mann−Whitney U two-tailed test. Adapted from Nguyen at al. [48].
