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. 2019 Jun 24;7(2):55. doi: 10.3390/vaccines7020055

Figure 1.

Figure 1

Schematic diagram of Zika virus clone ZIKBeHMR-2. The viral clone ZIKBeHMR-2 is a non-glycosylated mutant of chimeric ZIKV clone ZIKBeHMR-1, which has been described elsewhere [16]. The ZIKV structural and nonstructural genes are indicated. Chimeric ZIKBeHMR-1 genome contains the viral genomic region coding for C, prM and the N-terminal fragment (E-1 to E-436) of E from molecular clone BR15MC into the MR766MC backbone. The mutant ZIKBeHMR-2 bears the amino-acid substitutions I152T, T156I and H158Y. The residues Thr-152, Ile-156 and Tyr-148 have been identified in MR766 E protein.