Table 1.

Synthesized pirooxindoles and benzo[b]furan scaffolds 5a–r and their biological activity.

#	Compound	α-Amylase	α-Glucosidase	α-Amylase Selectivity b	α-Glucosidase Selectivity c
		IC50 (μM ± SD) a
1	5a	693.22 ± 0.10	465.12 ± 0.12	0.67	1.49
2	5b	747.08 ± 0.34	545.01 ± 1.09	0.72	1.37
3	5c	718.00 ± 0.27	585.11 ± 0.02	0.81	1.22
4	5d	728.13 ± 0.28	549.17 ± 1.06	0.75	1.32
5	5e	710.07 ± 0.10	554.12 ± 1.42	0.78	1.28
6	5f	670.14 ± 0.10	534.04 ± 1.09	0.79	1.25
7	5g	690.09 ± 0.06	554.12 ± 1.42	0.80	1.24
8	5h	589.04 ± 0.25	494.10 ± 0.04	0.83	1.19
9	5i	779.08 ± 0.51	684.12 ± 0.35	0.87	1.13
10	5j	39.02 ± 1.73	29.20 ± 0.33	0.74	1.33
11	5k	49.28 ± 1.09	39.10 ± 0.54	0.79	1.26
12	5l	558.07 ± 0.18	414.12 ± 0.52	0.74	1.37
13	5m	95.26 ± 0.27	69.11 ± 0.34	0.72	1.37
14	5n	185.23 ± 1.06	98.23 ± 1.24	0.53	1.88
15	5o	115.42 ± 0.07	68.18 ± 1.54	0.59	1.69
16	5p	488.02 ± 1.11	392.13 ± 1.07	0.80	1.24
17	5q	37.22 ± 1.49	26.29 ± 0.45	0.70	1.41
18	5r	22.61 ± 0.54	14.05 ± 1.03	0.62	1.60
STD	Acarbose (μM)	0.75 + 0.07	2.35 + 0.13	3.13	0.31

^a α-Amylase and α-glucosidase inhibitory activity is expressed as the mean ± SD of triplicate experiments. ^b Selectivity for α-amylase is defined as IC₅₀ (α-glucosidase)/IC₅₀ (α-amylase). ^c Selectivity for α-glucosidase is defined as IC₅₀ (α-amylase)/IC₅₀ (α-glucosidase).