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Tau isoforms in the human brain. Tau consists of a projection domain and a microtubule-assembly domain. The six tau isoforms (2N4R, 1N4R, 0N4R, 2N3R, 1N3R, AND 0N3R) are designated by the number of N inserts in the former and by the number of repeats R in the latter. Calculated pI’s indicate that the isoforms except 2N3R are basic proteins. The number of potential phosphorylation sites in each isoform is indicated.
