Figure 2.

Biological functions of lncRNAs. LncRNAs were shown to interact with protein coding genes and their transcripts to regulate gene expression. (A) Nuclear lncRNAs interact with chromatin remodelling factors and TFs to regulate the expression of neighbouring or distal genes. (B) Nuclear lncRNAs also regulate transcription and several other transcriptional events of RNA processing. (C) Cytoplasmic lncRNAs were shown to interfere with post-transcriptional regulation such as mRNA stability and degradation as well as translational regulation of mRNAs.