Figure 4.

Lethe regulates gene expression upon exposure to TNF-α, IL-1β and dexamethasone in fibroblasts. Activation of Lethe by either pro- or anti-inflammatory stimuli was found to inhibit expression of inflammatory genes by binding directly to RelA and preventing NF-κB binding to DNA. Therefore, Lethe is suggested to act as a negative regulator of NF-κB and the activation of the inflammatory response. GR, glucocorticoid receptor; NF-κB RE, NF-κB response element; RelA, transcription factor p65.