Table 2.

Inhibitory effect of 1,2-dihydroxyxanthone (1,2-DHX) on nitric oxide (NO) production by RAW 264.7 cells.

Compound	NO Inhibition (% of Control)
	0 h	6 h	14 h
1,2-DHX (25 μM)	56.6 ± 1.8	25.0 ± 2.8 *	n.i.
L-NAME (62.5 μM)	52.8 ± 5.0	50.7 ± 3.8	25.9 ± 2.7 **
Dexamethasone (6.25 μM)	55.9 ± 2.3	15.7 ± 4.9 *	n.i.

Macrophages were exposed to LPS and treated with 1,2-dihydroxyxanthone (1,2-DHX) at different times after stimulation: 0 (simultaneously with the stimulus), 6, or 14h after stimulation. Results are the mean ± SEM (n ≥ 3). n.i. = no inhibition. * p < 0.001, ** p < 0.05. N-nitro-L-arginine methyl ester (L-NAME) and dexamethasone were used as positive controls.