Table 2.
In vivo cellular tropism of human norovirus (HuNoV).
| Cell Type | Immunocompetent Host | Immunocompromised Host | ||
|---|---|---|---|---|
| Acute 1 | Persistent 1 | Acute 1 | Persistent 1 | |
| Epithelial cells | N.D. | N.D. | + 3 | ++ 4 |
| Tuft cells | N.D. | N.D. | N.D. | N.D. |
| Macrophages | N.D. | N.D. | N.D. | + 5 |
| Dendritic cells | + 2 | N.D. | N.D. | + 5 |
| B cells | + 2 | N.D. | N.D. | – 5 |
| T cells | N.D. | N.D. | N.D. | +++ 5 |
Notes:1 N.D. = not done. 2 Detected viral antigen in tissue section of chimpanzees [43]. 3 Detected viral antigen in tissue sections of gnotobiotic pigs [27,28]. 4 Detected viral antigen and non-structural proteins [41]. 5 Stained for viral antigen in cells and non-structural proteins detected in the lamina propria [41].