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. 2019 Jun 13;24(12):2211. doi: 10.3390/molecules24122211

Figure 1.

Figure 1

(A) A simplified schematic for the RNAi pathway. (B) The canonical siRNA that has 19 bp sequence plus a unilateral 2 nt overhang at 3′ end. (C) Asymmetric siRNA (aiRNA) with a 20 nt antisense strand and 15 nt sense strand. (D) Small internally segmented RNA (sisiRNA) containing the segmented sense strand. (E) The single-stranded siRNA that can engaging RNAi machinery. (F) Dicer substrate siRNA (DsiRNA) can be processed into mature canonical siRNA by Dicer cleavage. (G) Short hairpin RNA (shRNA) has a siRNA duplex plus a hairpin loop.