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. 2019 Jun 13;24(12):2211. doi: 10.3390/molecules24122211

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© 2019 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The schematic structure of spherical siRNA nanoparticle. (B) Preparation of spherical siRNA by immobilizing siRNA and short-PEG to Au nanoparticle surface in two steps. (C,D) Spherical siRNA (Cy3-labeled) showed strong cell uptake on HeLa cells. (E) The structure of spherical siRNA (RNA–Au NPs) can protect siRNA (dsRNA) from degradation in serum. (F) Spherical siRNA penetrates through mouse skin and delivers siRNA into in the cytoplasm of epidermal cells. (G) The localization of Au content in coronal brain sections of mice injected intracranially with spherical siRNA. Adapted with permission from [117,119,121,126].