Figure 8.

Time of appearance of splenic cytokines and polyphenol effects. In A, at day 8, cytokine release by PMA and PMA/polyphenol-stimulated splenocytes, respectively, is indicated. In homo mice, polyphenols abrogate release of IL-12, IL-10 and TNF-α. In hetero and wt mice, effects are less evident in view of a likely delayed maturation of immune cells. In B, at day 30, cytokine release by PMA and PMA/polyphenol-stimulated splenocytes, respectively, is indicated. Maturation of immune cells is more marked in homo and hetero mice than in wt mice. Polyphenols dampen the release of regulatory and inflammatory cytokines in homo and hetero mice and to a lesser extent in wt mice.