Table 5.
Association between intra-dialytic systolic BP change (per 10 mmHg higher) and difference in slope of cognitive tests (per year change)
| Type of Test | Cognitive test | Scoring | n | N | Unadjusted Slope^ | p | Adjusted Slope^ (95% CI) | p |
|---|---|---|---|---|---|---|---|---|
| Summary Score | Memory | SD* | 300 | 645 | 0.00 (−0.02, 0.01) | 0.7 | 0.00 (−0.02, 0.01) | 0.7 |
| Summary Score | Executive Function | SD* | 300 | 645 | −0.02 (−0.03, 0.00) | 0.04 | −0.02 (−0.03, 0.00) | 0.1 |
| Screening | MMSE | No. correct | 314 | 785 | −0.01 (−0.08, 0.06) | 0.8 | −0.01 (−0.07, 0.06) | 0.9 |
| Primarily Memory |
Short Delayed Recall | No. correct | 312 | 779 | −0.02 (−0.07, 0.03) | 0.4 | −0.02 (−0.06, 0.02) | 0.3 |
| Delayed Recall | No. correct | 312 | 774 | −0.03 (−0.08, 0.02) | 0.2 | −0.03 (−0.07, 0.01) | 0.2 | |
| Word Recognition | No. correct | 312 | 775 | −0.05 (−0.10, −0.01) | 0.03 | −0.05 (−0.09, −0.01) | <0.01 | |
| Primarily Executive Function |
Block Design | No. completed | 311 | 752 | −0.18 (−0.34, −0.02) | 0.03 | −0.15 (−0.30, 0.00) | 0.1 |
| Digit Symbol Substitution |
No. completed | 296 | 676 | −0.11 (−0.35, 0.12) | 0.4 | −0.07 (−0.29, 0.15) | 0.5 | |
| Digits Forward | No. correct | 187 | 452 | 0.03 (−0.02, 0.07) | 0.2 | 0.03 (−0.01, 0.07) | 0.2 | |
| Digits Backward | No. correct | 186 | 451 | 0.00 (−0.04, 0.05) | >0.99 | 0.00 (−0.04, 0.05) | 0.9 | |
| Trail Making Part A | Time to completion (sec) |
302 | 693 | 0.49 (−0.86, 1.83) | 0.5 | 0.44 (−0.89, 1.77) | 0.5 | |
| Trail Making Part B | Time to ompletion (sec) |
299 | 681 | 0.92 (−0.54, 2.38) | 0.2 | 0.66 (−0.69, 2.01) | 0.3 | |
| Mental Alternations | No. correct | 187 | 453 | 0.04 (−0.10, 0.18) | 0.6 | 0.05 (−0.09, 0.18) | 0.5 | |
| COWAT (Animals) | No. correct | 187 | 453 | −0.12 (−0.23, −0.01) | 0.04 | −0.10 (−0.21, 0.01) | 0.1 | |
| COWAT (Supermarket) | No. correct | 187 | 454 | −0.07 (−0.20, 0.06) | 0.3 | −0.05 (−0.18, 0.08) | 0.4 |
^
Slope is the rate of change in the cognitive test per year.
*
Summary scores represent a per standard deviation change, with a mean of zero and SD of 1.
Negative coefficients are associated with steeper decline in scores over time except on the Trail Making Tests.
Bold indicates statistically significant differences over time.
n = number of unique patients and N = number of follow up visits. The Digits, Mental Alternations, and COWAT tests were added halfway through study enrollment.
MMSE, Mini-Mental State Examination; COWAT, controlled oral word association test.