Table 2.
Top hits for up- or down-regulated genes found in all three studies described in the text. Log 2 expression values are shown, where a value of 0 indicates normal expression, and positive or negative values denote up- or down-regulation, respectively. Genes with values more than +/− 0.75 are shown in italics, and those with values more than +/− 1.25 are shown in bold.
| Gene ID | Found in All 3 Studies | Putative Location of Encoded Protein | Ring (9 HPI) Expression Value (Log2 Ratio) in 3D7 |
Trophozoite (28 HPI) Expression Value (Log2 Ratio) in 3D7 | Essential? |
|---|---|---|---|---|---|
| PF3D7_0102200 | Ring-infected erythrocyte surface antigen | Dense Granules (Merozoites) | 0.8 | −2.52 | Unknown |
| PF3D7_0608800 | Ornithine aminotransferase | Cytoplasm | −1.74 | 0.7 | No |
| PF3D7_0903700 | Alpha tubulin 1 | Microtubule | −1.3 | −0.08 | No |
| PF3D7_0930300 | Merozoite surface protein 1 | Plasma Membrane | −0.59 | −1.52 | Yes |
| PF3D7_1008700 | Tubulin beta chain | Microtubule | −1.53 | −0.02 | Yes |
| PF3D7_1246200 | Actin I | Actin Filament/Cytoskeleton | −0.55 | −1.05 | Yes |
| PF3D7_1324900 | L-lactate dehydrogenase | Cytosol | −0.76 | 0.49 | Yes |
| PF3D7_1407900 | Plasmepsin I | DV | 1.17 | −1.01 | Yes |