Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 13;8(2):77. doi: 10.3390/pathogens8020077

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Organ-specific mosquito antiviral strategies. (A): In the Ae. aegypti system, DENV enters through blood meal and replicates inside the mid-gut. From the mid-gut, DENV is released to the hemolymph, salivary glands, and brain. (B): Inside the mid-gut epithelial cells, (1) RNA interference limits viral replication and (2) immune signaling pathways generate AMPs that block the virus inside the cells and also diffuse out to the hemolymph. (C): In the hemocytes, (3) complement-like factor AaMCR and its scavenger receptor AaSR-C interact with the signaling AMP production. (4) Phenoloxidase (PO) encapsulates DENV in the hemolymph. (D): In the neurons, AaHig binds to the envelop protein of the DENV as well as the cell membrane to block endocytosis. (E): In the salivary glands (5) extracellular cecropin-like peptides inhibit the virus and (6) intracellular cystatin and ankyrin repeat-containing protein (ARP) limit virus production.