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Regulation of the methionine cycle and GSH synthesis by SAM and SAH. Abbreviations: BHMT, betaine homocysteine methyltransferase; CBS, cystathionine synthetase; GNMT, glycine N-methyltransferase; MATI/III, methyladenosyltransferase I/III; MATII, methyladenosyltransferase II; MT, methyltransferase; MTHFR, methyltetrahydrofolate reductase; SAHH, S-adenosylhomocysteine hydroxylase. The blue arrows indicate activation; the red blunt arrows indicate inhibition.
