Table 7.

Statistical Analysis—Plackett–Burman Design of experiment.

Factors	Y1 (nm)		Y2 (mV)		Y3 (%)		Y4
	Coefficient	p-Value	Coefficient	p-Value	Coefficient	p-Value	Coefficient	p-Value
α0	483.41	0.0269	−12.86	0.0279	63.93	0.0200	0.47	0.0469
X1	−16.59	0.2563	0.43	0.1323	−4.51	0.0098	0.052	0.4253
X2	45.53	0.0499	−0.077	0.5508	3.02	0.0214	−0.071	0.2875
X3	−81.08	0.0165	−3.01	0.0190	−5.33	0.0070	−0.28	0.0082
X4	96.76	0.0117	6.93	0.0083	−2.26	0.0373	−0.20	0.0264
X5	−73.76	0.0198	−2.16	0.0265	−1.95	0.0491	e	e
X6	96.59	0.0117	−0.18	0.3000	e	e	−0.088	0.2064
X7	39.91	0.0633	−0.68	0.0842	1.50	0.0794	−0.097	0.1719
X8	e	e	0.51	0.1112	−1.30	0.1021	0.069	0.2987

Y₁—average particle size; Y₂—Zeta-potential; Y₃—encapsulation efficiency; Y₄—polydispersity index; α₀—constant; X₁—docetaxel amount in organic phase (mg); X₂—PLGA amount in organic phase (mg); X₃—surfactant concentration in aqueous phase (%); X₄—surfactant type; X₅—size reduction process; X₆—solvent type; X₇—vortexing speed in emulsification step (rpm); X₈—stirrer speed in hardening step (rpm); e—Factors were not modeled by software.