Table 1.

In vitro effect of phytochemicals against colorectal cancer by miRNA regulation.

Phytochemical	Cell Line	MiRNA Affected	Target(s) and Effect	Reference
Curcumin	RKO, SW480	miR-17-5p↓ miR-20a↓ miR-27a↓	ZBTB10↑, ZBTB4↑ Sp1↓, Sp3↓, Sp4↓	[25]
	RKO, HCT116	miR-21↓	PDCD4↑	[26]
	SW480	miR-130a↓	Wnt↓, B-catenin↓, Nkd2↑	[28]
CDF	HCT-116, SW620, HT-29	miR-21↓	PTEN↑	[33]
	HCT-116, SW620	miR-34a↑ miR-34c↑	Notch-1↓	[31]
RL197	RKO, SW480	miR-17-5p↓ miR-20a↓ miR-27a↓	ZBTB10↑, ZBTB4↑ Sp1↓, Sp3↓, Sp4↓	[25]
Resveratrol	DLD-1, SW480	miR-34a↑	E2F3↓, Sirt1↓	[45]
	SW480	miR-663↑	TGFβ1↓	[43]
Baccharin + Drupanin	DLD-1	miR-143↑	MAPK/Erk5↓ C-myc↓	[55]
CDODA-Me	RKO, SW480	miR-27a↓	ZBTB10↑, Myt1↑ Sp1↓, Sp3↓, Sp4↓	[57]
Sulforaphane	RKO	miR-21↓	hTERT↓, HDAC1↓	[59]
	NCM460, NCM356	miR-23b↑ miR-27b↑	FZD7↓ MAP3K1↓	[60] [63]
	NCM460, NCM356	miR-155↓	SOCS1↑, AKT↓	[60,66]
EVOO	Caco-2	miR-23a↓ miR-301a↓	CB1↑	[71]
A-mangostin	DLD-1	miR-143↑	MAPK/Erk5 ↓	[73]
AKBA	SW620, HT29, HCT116	miR-200b↑ miR-200c↑ miR-let7a↑	Vimentin↓ CDK6↓ E-cadherin↑	[76]
Spica Prunellae	HCT-8	miR-34a↑	Notch-1↓ Notch-2↓ Bcl-2↓	[82]
Ellagic Acid and Urolithins	HT-29, Caco-2	miR-215↑ miR-224↓	CDKN1A↑	[87]
Rosemary Extract	SW480	miR-15b↓	GCNT3↑	[90]
Methyl Jasmonate	SW620	miR-101↑	EZH2↓	[92]
HAG	HCT116, DLD-1, LOVO	miR-29b↑	MMP-2↓	[96]

Increase in expression levels of miRNAs and proteins are shown by an up arrow (↑) and decrease in expression levels of miRNA and protein are shown by a down arrow (↓).