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. 2019 Apr 29;12(2):65. doi: 10.3390/ph12020065

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Neural stem cell (NSCs) sources and their therapeutic applicability after cell transplantation. There are three main sources to generate NSCs: isolation from primary central nervous system (CNS) tissue; differentiation of pluripotent stem cells, and lineage reprogramming of somatic cells. After obtaining a considerable number of cells that fulfill the needs of cell transplantation cells can be applied. Once on the injury site, NSCs can be differentiated and also secrete paracrine factors that may also support neurological repair.