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Overview of the advantages and limitations of induced pluripotent stem cells generation and establishment from somatic cells.
| Advantages | Limitations |
|---|---|
| No ethical concerns | Risk of tumor formation |
| Evidence on a pluripotent profile (ES-like cells) | Epigenetic and genetic alterations |
| Highly flexible technique | Oncogenes reactivation |
| Derivation from any somatic cell | Expensive and time-consuming |
| Patient-specific source (no immune rejection) |
