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. 2019 Jun 8;11(6):535. doi: 10.3390/v11060535

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Norovirus polymerase and capsid dual type combinations of (A) Genogroup I (n = 1343) and (B) Genogroup II (n = 8294). Polymerase-capsid combinations denoted with an asterisk (*) were found in the CDC collection only. Polymerase-capsid combinations denoted with a hash (#) were found in GenBank only. NA: Not Assigned. Total polymerase breakdown for each type: GI.P1 (101), GI.P2 (47), GI.P3 (333), GI.P4 (145), GI.P5 (143), GI.P6 (83), GI.P7 (192), GI.P8 (19), GI.P9 (21), GI.Pa (13), GI.Pb (57), GI.Pc (8), GI.Pd (164), GI.Pf (4), GI.Pg (5), GI.Ph (1), GI.Pi (2), GII.P1 (14), GII.P2 (340), GII.P3 (21), GII.P4 (1728), GII.P5 (7), GII.P6 (9), GII.P7 (851), GII.P8 (32), GII.P12 (349), GII.P13 (23), GII.P15 (22), GII.P16 (2755), GII.P17 (425), GII.P20 (3), GII.P21 (276), GII.P22 (86), GII.P23 (69), GII.P24 (20), GII.P26 (1), GII.Pa (15), GII.Pc (5), GII.Pe (1008), GII.Pf (2), GII.Pg (148), GII.Ph (3), GII.Pj (1), GII.Pk (1), GII.Pm (6), GII.Pn (2), GII.Pp (1), GII.Pq (3). GII.P4 includes Den Haag (49), New Orleans (217), and 1462 sequences not typed to the variant level. Total capsid breakdown for each type: GI.1 (101), GI.2 (47), GI.3 (520), GI.4 (121), GI.5 (175), GI.6 (140), GI.7 (197), GI.8 (18), GI.9 (21), GII.1 (124), GII.2 (1333), GII.3 (580), GII.4 (4247), GII.5 (86), GII.6 (579), GII.7 (183), GII.8 (32), GII.9 (5), GII.10 (22), GII.12 (143), GII.13 (174), GII.14 (88), GII.16 (11), GII.17 (519), GII.20 (8), GII.21 (20), GII.22 (5), GII.23 (69), GII.24 (20), GII.25 (3), GII.26 (1), GIX.1 (22). GII.4 includes Den Haag (43), New Orleans (52), Sydney (2211), and nine typed outside our variant level threshold. Polymerase-capsid combinations that are not shown include GI.P8-GII.4 (1) was only found in GenBank and GI.P untypeable-GI.3 (5) and GI.Pi-GI.untypeable (2) which were found in strains sequenced in this study only. Sequences were downloaded from CaliciNet on September 21, 2018 and from GenBank on October 12, 2018. Sequence length used to type polymerase and capsid was at least 509 nt for GI and 497 nt for GII. The number of sequences available for each combination were calculated into quartiles separately for GI and GII. Each quartile was assigned a color transitioning from lighter to darker shades of blue for GI and green for GII.