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. Author manuscript; available in PMC: 2019 Jul 16.
Published in final edited form as: Cell Rep. 2018 Jul 10;24(2):355–365. doi: 10.1016/j.celrep.2018.06.033

Figure 4. Spontaneous Fluctuations in DS Astroglia Could Not Be Modulated by Pharmacological Manipulation.

Figure 4.

(A) ATP increased the frequency and amplitude of Ca2+ events in previously active cells (20 ROIs; p < 0.01).

(B and C) Purinergic receptor antagonist (20 μM PPADS; 25 ROIs, B; and 20 μM suramin; 18 ROIs, C) failed to modulate the Ca2+ fluctuations in DS4A.

(D–F) A1 adenosine receptor antagonist (DPCPX 20 μM; 18 ROIs; D), mGluR5 antagonist (10 μM MPEP; 42 ROIs; E), and TRPA inhibitor (50 μM HC030031; 20 ROIs; F) failed to modulate the Ca2+ fluctuations in DS4A. (Left) Representative traces are shown. (Right) Quantification of amplitude, frequency, and kinetics is shown.

*p < 0.01, **p < 0.01.