Table 1.
Genes included in the DMET 1.0 panel
| P450 Enzymes | Non-P450 enzymes | Transporters | Other | ||||
|---|---|---|---|---|---|---|---|
| CYP1A1 | CYP4F2 | ADH1A | CROT | NQO1 | ABCB1 | SLC15A2 | AHR |
| CYP1A2 | CYP4F3 | ADH1B | DYPD | SULT1A1 | ABCB4 | SLC16A1 | NR1I2 |
| CYP1B1 | CYP4F8 | ADH4 | EPHX1 | SULT1A2 | ABCB7 | SLC19A1 | NR3C1 |
| CYP2A13 | CYP4Z1 | ADH5 | FMO1 | SULT1A3 | ABCB11 | SLC22A1 | PPARD |
| CYP2A6 | CYP46A1 | ADH6 | FMO2 | SULT1B1 | ABCC1 | SLC22A2 | PPARG |
| CYP2A7 | CYPA1 | ADH7 | FMO3 | SULT1C1 | ABCC2 | SLC22A3 | RALBP1 |
| CYP2B6 | CYP51A1 | ALDH1A1 | FMO4 | SULT1C2 | ABCC3 | SLC22A4 | RPL13 |
| CYP2B7P1 | CYP7A1 | ALDH2 | FMO5 | SULT1E1 | ABCC4 | SLC22A5 | SPG7 |
| CYP2C9 | CYP7B1 | ALDH3A1 | FMO6 | SULT2A1 | ABCC5 | SLC22A6 | XDH |
| CYP2C8 | CYP8A1 | AOX1 | GSTA1 | SULT2B1 | ABCC6 | SLC22A8 | |
| CYP2C19 | CYP8B1 | COA | GSTA2 | SULT4A1 | ABCG2 | SLC28A1 | |
| CYP2C18 | CYP11A1 | CHST1 | GSTA3 | TPMT | ATP7A | SLC28A2 | |
| CYP2D6 | CYP11B1 | CHST2 | GSTA4 | UGT1A1 | ATP7B | SLC28A3 | |
| CYP2E1 | CYP11B2 | CHST3 | GSTA5 | UGT1A3 | SLC5A6 | SLC29A1 | |
| CYP2F1 | CYP17A1 | CHST4 | GSTM2 | UGT1A4 | SLC7A5 | SLC29A2 | |
| CYP2J2 | CYP19A1 | CHST5 | GSTM3 | UGT1A6 | SLC7A7 | SLCO1A2 | |
| CYP281 | CYP20A1 | CHST6 | GSTM4 | UGT1A7 | SLC10A1 | SLCO1B1 | |
| CYP3A4 | CYP21A2 | CHST7 | GSTO1 | UGT1A8 | SLC10A2 | SLC1B3 | |
| CYP3A43 | CYP24A1 | CHST8 | GSTP1 | UGT2A1 | SLC13A1 | SLCO2B1 | |
| CYP3A5 | CYP26A1 | CHST9 | HNMT | UGT2B11 | SLC15A1 | ||
| CYP3A7 | CYP26C1 | CHST10 | MAOB | UGT2B15 | |||
| CYP4A11 | CYP27A1 | CHST11 | NAT1 | UGT2B28 | |||
| CYP4B1 | CYP27B1 | CHST13 | NAT2 | UGT2B4 | |||
| CYP4F11 | CYP39A1 | COMT | NNMT | UGT8 | |||
| CYP4F12 | POR | ||||||
Abbreviations: DMET, drug-metabolizing enzymes and transporters; SNP, single-nucleotide polymorphism.
The DMET assay and panel genotype samples for variations in 170 drug disposition genes, including 50 CYP450 genes, 72 non-CYP genes, 39 transporters and 9 other proteins involved in drug disposition. Assay genotyping identifies homozygote wild-type, homozygote variant or heterozygote alleles in 1256 SNPs and other genetic variation sites in these genes.