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. 2019 Jul 16;20(Suppl 8):551. doi: 10.1186/s12864-019-5867-y

Table 3.

Pearson’s linear correlation coefficient between the vIP of the wild-type nucleotide motifs and their normalized SBS frequency in the different gene regions

X Doublets XN Triplets NXN Quadruplets NXNN Quintuplets NNXNN Sextuplets NNXNNN
Missense mutations in exons
All -0.39 -0.39 (<0.05) -0.35 (<0.01) -0.34 (<10−13) -0.31 (<10−51)
G -0.23 -0.54 (<0.05) -0.36 (<0.01) -0.32 (<10−6) -0.32 (<10−13)
C -0.81 -0.71 (<0.005) -0.59 (<10−5) -0.54 (<10−14) -0.48 (<10−56)
A 0.77 0.55 (<0.05) 0.39 (<0.001) 0.36 (<10−6) 0.23 (<10−17)
T -0.06 0.18 -0.05 -0.03 -0.07
Synonymous mutations in exons
All -0.48 -0.42 (<0.005) -0.39 (<10−8) -0.38 (<10−29) -0.34 (<10−109)
G -0.65 -0.67 (<0.005) -0.50 (<0.00005) -0.42 (<10−14) -0.33 (<10−32)
C -0.80 -0.68 (<0.05) -0.54 (<0.005) -0.53 (<10−13) -0.50 (<10−50)
A -0.59 0.02 -0.09 0.00 -0.05
T -0.87 0.00 -0.21 -0.17 (<0.05) -0.13 (<0.0005)
Mutations in introns
All -0.39 -0.42 (<0.005) -0.38 (<10−5) -0.36 (<10−24) -0.33 (<10−78)
G -0.27 -0.51 (<0.05) -0.36 (<0.05) -0.31 (<10−6) -0.23 (<10−11)
C -0.78 -0.70 (<0.05) -0.61 (<10−7) -0.55 (<10−20) -0.54 (<10−83)
A 0.80 0.67 (<0.05) 0.45 (<0.01) 0.22 (<0.005) 0.09 (<10−8)
T 0.07 0.41 0.34 (<0.005) -0.09 -0.11
Mutations in UTRs
All -0.43 -0.39 (<0.05) -0.35 (<0.005) -0.34 (<10−16) -0.32 (<10−57)
G -0.18 -0.47 -0.31 (<0.05) -0.25 (<0.01) -0.16 (<0.0001)
C -0.79 -0.71 (<0.05) -0.60 (<0.0001) -0.57 (<10−20) -0.53 (<10−67)
A 0.60 0.64 (<0.01) 0.54 (<0.05) 0.49 (<10−11) 0.28 (<10−15)
T -0.13 0.33 -0.02 0.00 -0.04

X indicates the position of the mutated nucleobase and N any base. The correlation coefficients that are statistically significant and for which the null hypothesis is rejected are underlined, with the P-values below α=0.05 reported in parentheses. Note that the increase in sample size, from doublet to sextuplet motifs, also contributes to the increase of the statistical significance of the correlation