Table 4.
Slope of the regression lines of the normalized SBS frequency as a function of the vIP of the corresponding wild-type nucleotide motifs in the different gene regions
| X | Doublets XN | Triplets NXN | Quadruplets NXNN | Quintuplets NNXNN | Sextuplets NNXNNN |
|---|---|---|---|---|---|
| Missense mutations in exons | |||||
| All | -0.6 | -1.1 | -1.1 | -1.3 | -1.5 |
| Synonymous mutations in exons | |||||
| All | -1.4 | -1.8 | -2.1 | -2.4 | -2.6 |
| Mutations in introns | |||||
| All | -1.8 | -3.7 | -3.7 | -4.4 | -5.3 |
| Mutations in UTRs | |||||
| All | -0.9 | -1.4 | -1.4 | -1.5 | -1.7 |
X indicates the position of the mutated nucleobase and N any base