Table 2.
Anti-CHIKV activities of daphnanes 55–66.
| Compound | CHIKV EC50 | SI | |
|---|---|---|---|
| Daphnanes | |||
| 55 | Resiniferatoxin | 1.8 ± 0.2 | 2.3 |
| 56 | Trigocherrierin A | 0.6 ± 0.1 | 71.7 |
| 57 | Trigocherrin A | 1.5 ± 0.6 | 23 |
| 58 | Trigocherrin B | 2.6 ± 0.7 | 36 |
| 59 | Trigocherrin F | 3.0 ± 1.2 | 7.7 |
| 60 | Trigocherriolide A | 1.9 ± 0.6 | 2.4 |
| 61 | Trigocherriolide B | 2.5 ± 0.3 | 2.1 |
| 62 | Trigocherriolide C | 3.9 ± 1.0 | 2.7 |
| 63 | Trigocherriolide E | 0.7 ± 0.1 | 9.4 |
| 64 | Neoguillauminin A | 17.7 ± 0.8 | 2 |
| 65 | Codiapeltine A | 10.0 ± 2.3 | 5 |
| 66 | Codiapeltine B | 4.4 ± 0.5 | 11 |
| Chloroquine | 10 ± 5 | 8.9 | |
EC50s are given in μM; values are the median ± standard deviation calculated from at least three independent assays. SI, selectivity index, calculated as CC50 Vero/EC50 CHIKV. n.d. = not determined. Anti-CHIKV results obtained with the methodology from Bourjot et al. [21].