Table 5.

Proposed relationships between pharmacological profiles and analgesic/antipruritic effect of the psychotropic drugs studied.

Drugs	Receptors	Type of Analgesic/Antipruritic Effect (Animal Models or/and Clinical Studies)
Trazodone chlorprothixene carbamazepine mianserin	voltage-dependent sodium channels in the peripheral nervous system	diabetic neuropathy, postherpetic neuralgia
citalopram mianserin trazodone venlafaxine	cannabinoid or opioid receptors	supraspinal analgesia
mianserin	κ-opioid receptors	sex-dependent analgesia
tianeptine	μ-opioid receptors	sex-independent analgesia
tianeptine citalopram trazodone venlafaxine carbamazepine	no similarities in pharmacological profiles found	inflammatory pain/antidepressants (or has antidepressant action)
chlorprothixene	histamine receptors + possible TRP channel *	sex-independent antipruritic action
mianserin carbamazepine tianeptine	no similarities in pharmacological profiles found	sex-dependent antipruritic action

* interaction with TRP channel was shown for chlorpromazine and cis-thiothixene, which are similar to chlorprothixene in structure and function.