Table 1.
Transmission electron microscopy (TEM) size, polydispersity index (PDI), hydrodynamic size, and zeta potential of all mesoporous silica nanoparticles (MSNs) and 5-fluorouracil-loaded mesoporous silica nanoparticles.
| Nanoparticle | Mean Diameter (TEM) (nm ± Standard Deviation) | PDI (SD/mean)2 | Hydrodynamic Size (Nanoparticle Tracking Analysis) (nm ± SD) | Zeta Potential (mV) |
|---|---|---|---|---|
| MSN | 36.09 ± 7.08 | 0.0385 | 188 ± 51.6 | −9.8 ± 1 |
| CHITOSAN (CHIT)-MSN | 39.43 ± 7.22 | 0.0335 | 62.2 ± 16 | 32.4 ± 0.4 |
| 2% Polyethylene glycol (PEG)-CHIT-MSN | 40.75 ± 7.11 | 0.0422 | 12 ± 3.3 | 17.0 ± 16.5 |
| 5% PEG-CHIT-MSN | 40.37 ± 7.70 | 0.0364 | 54.8 ± 2.1 | 7.4 ± 0.7 |
| 2% PEG-CHIT-MSN-5FU | 48.32 ± 8.20 | 0.0287 | 54.8 ± 40.7 | 11.2 ± 7.0 |
| 5% PEG-CHIT-MSN-5FU | 64.54 ± 25.11 | 0.1514 | 47.4 ± 5.5 | 3.4 ± 0.0 |