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. 2019 Jun 17;7(2):52. doi: 10.3390/vaccines7020052

Figure 1.

Figure 1

Figure 1

Features of the prepared Al-nanocarriers. (A) Transmission electron microscope (TEM) image of phospholipid bilayer-coated aluminum oxide nanoparticles (PLANs) displays the spherical shape and a size of 30 nm of the Al-nanocarriers (the inserted panel showing phospholipid coatings with thickness of around 5 nm observed with uranyl acetate negative staining). (B) TEM image of PEG-PLANs displays the spherical shape and a size of 30 nm of the Al-nanocarriers (the inserted panel showing phospholipid coatings with thickness of around 10 nm observed with uranyl acetate negative staining and the inexplicable presence of certain nano-sticks). (C) Fourier transform infrared spectroscopy (FTIR) spectra of aluminum microparticles (AMs) of Al(PO4)3, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and PLANs indicate, by comparative analysis, formation of covalent bonds between phosphate group and Al, as evidenced by a characteristic peak at ~1125 cm−1 which is resulted from the vibrations of Al–O–P. (D) Ovalbumin (OVA) release curves of the Al-based nanocarriers in different media at 37 °C showing trivial cargo release from these carriers (n = 3).