Table 1.

Characteristics of tumors (WT = BRCA wild type breast cancer, BRCA1, BRCA2 = breast cancer in BRCA1/BRCA2 mutation carriers, ER = estrogen receptor, PR = progesterone receptor, HER2 = human epidermal growth factor receptor 2, CK = cytokeratin, EGFR = epidermal growth factor receptor, CLDN = claudin)

Characteristics		WT (N = 116)		BRCA1 (N = 62)		BRCA2 (N = 59)		WT v BRCA1	p-value (Chi = square or Fisher’s test (if cells < 5))*
		N	Col %	N	Col %	N	Col %		WT v BRCA2	BRCA1 v BRCA2	WT v BRCA1/2
Age at diagnosis	<50y	79	68	47	76	38	64	0.282	0.623	0.170	0.721
	> = 50y	37	32	15	24	21	36
Tumor grade	1	29	25	1	2	4	7	<.001	0.006	0.021	<.001
	2	37	32	12	19	22	37
	3	31	27	40	65	26	44
	Unknown	19	16	9	15	9	15
Tumor size	< 2 cm	73	63	28	45	31	53	0.152	0.272	0.411	0.147
	2-5 cm	35	30	26	42	20	34
	> 5 cm	2	2	1	2	3	5
	Unknown	6	5	7	11	7	12
Tumor morphology	Invasive ductal carcinoma	83	72	56	90	47	80	0.027	0.327	0.072	0.068
	Invasive lobular carcinoma	8	7	0	0	5	8
	Invasive ductal+lobular carcinoma	6	5	0	0	2	3
	Carcinoma – undefined	4	3	2	3	3	5
	Other	15	13	4	6	2	3
ER	Negative	28	24	47	76	13	22	<.001	0.448	<.001	<.001
	Positive	78	67	14	23	45	76
	Unknown	10	9	1	2	3	5
PR	Negative	42	36	49	79	23	39	<.001	0.89	<.001	0.001
	Positive	68	59	11	18	34	58
	Unknown	6	5	2	3	4	7
HER2	Negative	77	66	43	69	22	37	0.887	<.001	<.001	0.003
	Positive	22	19	13	21	32	54
	Unknown	17	15	6	10	7	12
CK5	Negative	78	67	28	45	44	75	<.001	0.702	<.001	0.001
	Positive	9	8	27	44	5	8
	Unknown	29	25	7	11	12	20
CK14	Negative	89	77	45	73	49	83	0.012	0.999	0.030	0.129
	Positive	5	4	10	16	3	5
	Unknown	22	19	7	11	9	15
EGFR	Negative	76	66	52	84	52	88	0.585	0.052	0.209	0.122
	Positive	10	9	5	8	1	2
	Unknown	30	26	5	8	8	14
CLDN3	Negative	107	92	24	39	50	85	<.001	0.039	<.001	<.001
	Positive	1	1	36	58	4	7
	Unknown	8	7	2	3	7	12
CLDN4	Negative	6	5	6	10	0	0	0.423	0.094	0.999	0.059
	Positive	100	86	56	90	58	98
	Unknown	10	9	5	8	3	5
CLDN7	Negative	109	94	62	100	57	97	n/a	0.339	0.475	0.999
	Positive	0	0	0	0	1	2
	Unknown	7	6	0	0	3	5
E-cadherin	Negative	10	9	9	15	16	27	0.296	0.002	0.081	0.016
	Positive	89	77	48	77	40	68
	Unknown	17	15	5	8	5	8

*unknown/undetermined values are excluded from analysis