Table 4.
Demography, baseline (pre-bronchodilator) and maximal (post-bronchodilator) PFTs, in four imaging-based clusters
| Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | P value | |
|---|---|---|---|---|---|
| N = 100 | N = 80 | N = 141 | N = 85 | ||
| Demography | |||||
| GOLD (%) (0/1/2/3/4) | 62/23/14/1/0 | 57/20/20/2/0 | 6/24/51/16/3 | 2/0/12/46/40 | < 0.0001 |
| Strata (%) (2/3/4) | 62/37/1 | 57/40/2 | 6/74/19 | 2/12/86 | < 0.0001 |
| BODE index |
0.28 (0.61) |
0.60 (1.12) |
1.31 (1.78) |
3.99 (2.00) |
< 0.0001 |
| Sex (Female %) | 32 | 64 | 34 | 41 | 0.00015 |
| Race (White/African-American/Other) | 88/6/6 | 75/20/5 | 91/4/5 | 84/12/5 | 0.0088 |
| Age (yrs.) |
64.91 (7.11) |
66.59 (7.92) |
69.37 (5.94) |
65.67 (7.92) |
< 0.0001 |
| BMI (kg/m2) |
28.67 (4.43) |
30.76 (4.55) |
28.49 (4.6) |
25.68 (4.44) |
< 0.0001 |
| PFT Baseline lung function a | |||||
| FEV1% predicted |
88 (18) |
79 (16) |
59 (20) |
31 (15) |
< 0.0001 |
| FVC % predicted |
97 (14) |
88 (14) |
85 (18) |
71 (19) |
< 0.0001 |
| FEV1/FVC × 100 |
68 (10) |
68 (9) |
51 (11) |
32 (10) |
< 0.0001 |
| PFT Maximal lung function b | |||||
| FEV1% predicted |
95 (17) |
86 (16) |
68 (19) |
37 (17) |
< 0.0001 |
| FVC % predicted |
101 (14) |
91 (14) |
94 (17) |
80 (20) |
< 0.0001 |
| FEV1/FVC × 100 |
72 (10) |
71 (9) |
53 (11) |
34 (12) |
< 0.0001 |
Data presented as number (%) or mean (SD)
aPre-bronchodilator values
bPost-bronchodilator values after six to eight puffs of albuterol. Full names of each variable were described in Abbreviations used. BODE indexes for 24 subjects were not available