Table 2.
Significantly changed proteins from the t-test analysis at 5% FDR along with their concentrations and fractions of total protein in patient and control samples.
| Protein | Gene | p Value | [PV]/[N] 1 | Peptides | Conc. (pmol/mg) | Fraction of Total Protein% | ||
|---|---|---|---|---|---|---|---|---|
| N | PV | N | PV | |||||
| Transferrin receptor protein 1 | TFRC | 3.30 × 10−4 | 13 | 19 | 0.03 | 0.46 | 2.80 × 10−4 | 3.91 × 10−3 |
| Heparanase | HPSE | 2.10 × 10−5 | 11 | 11 | 0.05 | 0.82 | 3.18 × 10−4 | 5.00 × 10−3 |
| Plasminogen activator inhibitor 1 | SERPINE1 | 3.90 × 10−3 | 5.9 | 6 | 0.05 | 0.37 | 2.39 × 10−4 | 1.66 × 10−3 |
| Angiogenin | ANG | 2.00 × 10−5 | 5.4 | 3 | 0.11 | 0.63 | 1.83 × 10−4 | 1.04 × 10−3 |
| Histone H4 | HIST1H4A | 2.00 × 10−3 | 5.4 | 5 | 0.3 | 2.83 | 3.38 × 10−4 | 3.21 × 10−3 |
| Cathelicidin antimicrobial peptide | CAMP | 4.60 × 10−6 | 4.9 | 5 | 0.68 | 3.73 | 1.31 × 10−3 | 7.20 × 10−3 |
| Neurogenic locus notch homolog protein 3 | NOTCH3 | 5.30 × 10−3 | 4.3 | 8 | 0.02 | 0.12 | 5.62 × 10−4 | 2.93 × 10−3 |
| Lysozyme C | LYZ | 2.90 × 10−4 | 4.2 | 8 | 0.82 | 2.44 | 1.35 × 10−3 | 4.03 × 10−3 |
| Histone H3 | HIST2H3PS2 | 1.20 × 10−3 | 4.2 | 4 | 0.28 | 1.27 | 4.38 × 10−4 | 1.96 × 10−3 |
| L-selectin | SELL | 2.80 × 10−3 | 4.2 | 4 | 0.05 | 0.21 | 2.31 × 10−4 | 8.66 × 10−4 |
| Lactotransferrin | LTF | 3.70 × 10−3 | 4 | 23 | 0.27 | 1.09 | 2.10 × 10−3 | 8.54 × 10−3 |
| Vinculin | VCL | 1.20 × 10−3 | 3.2 | 13 | 0.08 | 0.2 | 9.44 × 10−4 | 2.43 × 10−3 |
| Multimerin-1 | MMRN1 | 1.80 × 10−3 | 3.1 | 32 | 0.39 | 1 | 5.35 × 10−3 | 1.38 × 10−2 |
| Beta-2-microglobulin | B2M | 2.10 × 10−7 | 2.7 | 6 | 2.52 | 6.83 | 3.46 × 10−3 | 9.37 × 10−3 |
| Nidogen-2 | NID2 | 9.80 × 10−3 | 2.7 | 6 | 0.02 | 0.04 | 2.57 × 10−4 | 6.52 × 10−4 |
| Amyloid beta A4 protein | APP | 3.40 × 10−4 | 2.6 | 12 | 0.53 | 1.35 | 4.60 × 10−3 | 1.18 × 10−2 |
| Serglycin | SRGN | 1.30 × 10−3 | 2.4 | 5 | 1.51 | 3.25 | 2.66 × 10−3 | 5.73 × 10−3 |
| Platelet glycoprotein V | GP5 | 2.90 × 10−3 | 2.3 | 11 | 0.18 | 0.57 | 1.11 × 10−3 | 3.49 × 10−3 |
| Retinol-binding protein 4 | RBP4 | 2.30 × 10−4 | 2.1 | 13 | 4.65 | 9.59 | 1.07 × 10−2 | 2.21 × 10−2 |
| Lipopolysaccharide-binding protein | LBP | 7.80 × 10−4 | 2.1 | 12 | 1.44 | 3.32 | 7.69 × 10−3 | 1.77 × 10−2 |
| TGFβ-induced protein ig-h3 | TGFBI | 2.20 × 10−3 | 2 | 12 | 0.19 | 0.41 | 1.41 × 10−3 | 3.07 × 10−3 |
| Properdin | CFP | 8.80 × 10−4 | 1.9 | 19 | 6.74 | 12.83 | 3.45 × 10−2 | 6.58 × 10−2 |
| Galectin-3-binding protein | LGALS3BP | 4.10 × 10−3 | 1.9 | 27 | 5.23 | 10.74 | 3.42 × 10−2 | 7.02 × 10−2 |
| Inter-alpha-trypsin inhibitor heavy chain H3 | ITIH3 | 6.10 × 10−3 | 1.9 | 29 | 1.53 | 3.15 | 1.53 × 10−2 | 3.15 × 10−2 |
| Alpha-1-microglobulin | AMBP | 2.2 × 10−4 | 1.8 | 17 | 7.75 | 14.69 | 3.02 × 10−2 | 5.73 × 10−2 |
| Platelet factor 4 | PF4 | 5.60 × 10−3 | 1.8 | 7 | 124.41 | 288.88 | 1.35 × 10−1 | 3.13 × 10−1 |
| Complement component C7 | C7 | 2.50 × 10−3 | 1.7 | 47 | 11.11 | 21.7 | 1.04 × 10−1 | 2.03 × 10−1 |
| Complement C1q subcomponent subunit A | C1QA | 1.20 × 10−3 | 1.5 | 18 | 72.33 | 114.86 | 1.88 × 10−1 | 2.99 × 10−1 |
| Histidine-rich glycoprotein | HRG | 4.00 × 10−3 | 1.5 | 22 | 18.28 | 31.2 | 1.09 × 10−1 | 1.86 × 10−1 |
| N-acetylmuramoyl-L-alanine amidase | PGLYRP2 | 5.90 × 10−3 | 1.5 | 17 | 2.24 | 3.37 | 1.39 × 10−2 | 2.10 × 10−2 |
| Clusterin | CLU | 1.10 × 10−3 | 0.75 | 19 | 31.13 | 23.19 | 1.63 × 10−1 | 1.22 × 10−1 |
| Apolipoprotein A-I | APOA1 | 2.70 × 10−3 | 0.73 | 41 | 857.47 | 652.78 | 2.64 | 2.01 |
| Apolipoprotein A-II | APOA2 | 2.40 × 10−3 | 0.71 | 11 | 177.37 | 126.08 | 1.98 × 10−1 | 1.41 × 10−1 |
| Apolipoprotein D | APOD | 9.60 × 10−4 | 0.6 | 13 | 61.85 | 37.16 | 1.49 × 10−1 | 8.98 × 10−2 |
| Fibulin-1 | FBLN1 | 3.40 × 10−3 | 0.54 | 20 | 3.01 | 1.63 | 2.24 × 10−2 | 1.21 × 10−2 |
| Phosphatidylinositol-glycan-specific phospholipase D | GPLD1 | 4.60 × 10−3 | 0.5 | 9 | 0.19 | 0.11 | 1.74 × 10−3 | 1.04 × 10−3 |
| Peroxiredoxin-6 | PRDX6 | 5.50 × 10−3 | 0.44 | 4 | 4.45 | 2.93 | 1.11 × 10−2 | 7.35 × 10−3 |
| Salivary acidic proline-rich phosphoprotein 1/2 | PRH1 | 2.90 × 10−3 | 0.3 | 3 | 0.19 | 0.06 | 3.23 × 10−4 | 1.01 × 10−4 |
1 Fold change (Patients [PV]/Controls [N].