. 2019 May 30;6(2):61. doi: 10.3390/medicines6020061

Table 1.

Zebrafish orthologs of human genes involved in neurodegenerative disease pathogenesis.

Disease	Protein	Human Gene	Zebrafish Gene	Amino Acid Similarity (%)	Reference
Alzheimer’s Disease	Amyloid precursor protein	APP GeneID: 351 Locus: 21q21.2 Protein length: 695	appa GeneID: 58083 Chromosome: 1 Protein length: 738	74	[41]
			appb GeneID: 170846 Chromosome: 9 Protein length: 694	77
	Presenilin-1	PSEN1 GeneID: 5663 Locus: 14q24.3 Protein length: 467	psen1 GeneID: 30221 Chromosome: 17 Protein length: 456	75	[42]
	Presenilin-2	PSEN2 GeneID: 5664 Locus: 1q31-q42 Protein length: 448	psen2 GeneID: 58026 Chromosome: 1 Protein length: 441	76	[43]
	β-secretase	BACE1 GeneID: 23621 Locus: 11q23.2-q23.3 Protein length: 501	bace1 zgc:77409 GeneID: 403005 Chromosome: 15 Protein length: 505	82	[44]
	β-secretase	BACE2 GeneID: 25825 Locus: 21q22.2-q22.3 Protein length: 518	bace2 zgc:103530 GeneID: 449818 chromosome: 15 Protein length: 462		[45]
	γ-secretase	PSENEN GeneID: 55851 Locus: 19q13.12 Protein length: 101	psenen GeneID: 402810 chromosome: 15 Protein length: 101	91	[46,47]
		NCSTN Gene ID: 23385 Locus: 1q23.2 Protein length: 709	ncstn GeneID: 494449 chromosome: 2 Protein length: 707	56	[48]
		APH1b Gene ID: 83464 Locus: 15q22.2 Protein length: 257	aph1p Gene ID: 386808 chromosome: 7 Protein length: 258		[46]
	Apolipoprotein E (ApoE)	APOE GeneID:348 Locus: 19q13.32 Protein length: 317	apoea Gene ID: 553587 chromosome: 19 Protein length: 269	27.5	[49]
	Apolipoprotein E (ApoE)		apoeb Gene ID: 30314 chromosome: 16 Protein length: 281		[50]
	Sortilin related receptor 1 (Sorl1)	SORL1 GeneID: 6653, Locus:11q24.1 Protein length: 2214	sorl1 Gene ID: 497306, chromosome: 15 Protein length: 2213	64	[51]
Parkinson’s Disease	DJ-1	DJ-1 Gene ID: 11315 Locus: PARK7 1p36.23 Protein length: 189	dj-1 Gene ID: 449674 Chromosome: 11 Protein length: 189	83	[52]
	Parkin	PRKN Gene ID: 5071 Locus: PARK2 6q25.2-q27 Protein length: 465	prkn Gene ID: 550328 Chromosome: 13 Protein length: 458	62	[53]
	PTEN-induced kinase 1 (PINK-1)	PINK1 Gene ID: 65018 Locus: PARK6 1p36 Protein length: 581	pink1 Gene ID: 494085 Chromosome: 6 Protein length: 574	54	[54]
	Leucine-rich repeat kinase2 (LRRK2)	LRRK2 GeneID: 120892 Locus: PARK8 12q12 Protein length: 2527	lrrk2 GeneID: 559366 Chromosome: 25 Protein length: 1985	38	[55]
Huntington’s Disease	Huntingtin	HTT GeneID: 3064 Locus: 4q16.3 Protein length: 3144	htt GeneID: 30214 Chromosome: 1 Protein length: 3121	70	[56]
Amyotrophic Lateral Sclerosis (ALS)	Fused in sarcoma	FUS GeneID: 2521 Locus: 16p11.2 Protein length: 526	fus Gene ID: 394058 Chromosome: 3 Protein length: 541	63	[57]
Amyotrophic Lateral Sclerosis (ALS)	Tar DNA binding protein of 43 (TDP-43)	TARDBP GeneID: 23435 Locus: 1p36.22 Protein length: 414	tardpb GeneID: 325052 Chromosome: 6 Protein length: 412	71	[58]
Spinocerebellar Ataxia Type 1	Ataxin 1	ATXN1 GeneID: 6310 Locus: 6p23 Protein length: 815	atxn1a GeneID: 565841 Chromosome: 16 Protein length: 827	32	[59]
Spinocerebellar Ataxia Type 1			atxn1b GeneID: 557340 Chromosome: 19 Protein length: 781	42
Schizophrenia	Dystrobrevin binding protein	DISC1 Gene ID: 27185 Locus: 1q42.2 Protein length:854	disc1 GeneID: 407621 Chromosome: 13 Protein length: 994	53	[60]
Schizophrenia	Kinesin family member 17	KIF17 Gene ID: 57576 Locus: 1p36.12 Protein length:1029	kif17 GeneID:557863 Chromosome: 11 Protein length: 823	83	[61]