Table 2.

List of iminosugars and their inhibitory effects.

Amino Sugars	Glucosidase Inhibition	Other Anti-Tumor Activities	Ref (s)
Swainsonine	Lysosomal α-1-3- (IC50 0.70 nM) and α-1-6-mannosidase (Ki 40 nM) and Golgi α-mannosidase	Inhibits growth of tumor cells	[13]
1,4-Dideoxy-1,4-imino-D-mannitol	α-mannosidase, Lysosomal Golgi α-mannosidase II, glycogen phosphorylase	Human Glioblastoma and Melanoma Cells	[74]
1-Deoxymannojirimycin	α-1-2-mannosidase (IC50 0.02 mM), Golgi α-mannosidase II (IC50 400 µM)	Interact with recombinant tumor necrosis factor (rTNF) and recombinant interleukin 1 (rIL-1)	[75]
2-aminomethyl-5-(hydroxymethyl) pyrrolidine3,4-diol derivative	Jack bean α-Mannosidase (IC50 55 µM)	Inhibits growth of human glioblastoma cells and melanoma cells, DNA, synthesis of proteins	[74,76]
Castanospermine	α- and β-glucosidases	Inhibitor of breast cancer	[77]
1-deoxynojirimycin	Glucosidase I and II	Anti-metastatic activity, reduce adhesion of tumor cells to vascular endothelium, inhibit cellular transformation, prevent morphological differentiation of endothelial cells	[13]
(+)-Lentiginosine	amyloglucosidases	Inhibits ATPase and Chaperone Activity of Hsp90	[78]
Siastatin B	β-glucuronidase, NAG-ase	Antimetastatic activity	[13]