Table 2.
Inhibition of P. aeruginosa LecA-induced hemagglutination.
| Entry | Formulation | Hemagglutination Assay MIC (uM) 1 | Relative Potency 4 |
|---|---|---|---|
| 1 | D-galactose | 3125.0 | 1.0 |
| 2 | 100%-Modified D-galactose-NP | 6.31 | 495.2 |
| 3 | 50%-Modified D-galactose-NP | 3.15 | 992.1 |
| 4 | 25%-Modified D-galactose-NP | none 2 | - |
| 5 | 100%-Modified mannose-NP | none 3 | - |
1 MIC = minimal inhibitory concentration for the hemagglutination assay following two-fold serial dilutions of tested compounds; the MIC corresponds to the highest dilution resulting in the inhibition of LecA-induced hemagglutination based on the relative sugar concentration. 2 No inhibition of hemagglutination up to highest concentration evaluated (galactose concentration of 2.36 μM). 3 No inhibition of hemagglutination up to highest concentration evaluated (maltose concentration of 37.9 μM). 4 Relative potency based on concentration of galactose = (MIC(D-galactose)/MIC(ligand)).