Table 1.

Study eligibility criteria

Eligibility	Exclusion criteria
• Men or women 20–65 years of age	• Previous treatment with nifurtimox or benznidazole
• Positive serology for T. cruzi (at least two different techniques applied to the same blood sample) in the last 10 years	• Lack of compliance/tolerance to a 10-day run-in period
• No clinical suspicion, or active risk factors for, chronic cardiomyopathy	• Abnormal values in blood cell counts or laboratory tests for hepatic and renal function
• Negligible risk of vector T. cruzi re-infection	• Any medical/social condition hindering free participation
• Capable of complying with the planned study visits	• Current or planned pregnancy, or not using secure birth methods for women of childbearing age