Table 1.
Associations of ovarian cancer with pathogenic variants in homologous recombination genes among self-reported white women
| Gene | Median Age of PV Carriers (Casesa, Controlsb) | Crude Odds Ratio (CI) | p-value, Crudec | Adjusted Odds Ratio (CI) | p-value, Adjustedc | Case Carriers, No. (Non-Carriers)d | Control Carriers, No. (Non-Carriers) | p-value, z-teste |
|---|---|---|---|---|---|---|---|---|
| ATM | 55.0, 47.0 | 2.01. (1.15 to 3.64) | 0.03 | 1.72 (0.89 to 3.44) | 0.18 | 35 (4724) | 17 (4673) | 0.35 |
| BARD1 | 60.0, 34.5 | 1.59 (0.31 to 9.56) | 0.57 | 6.30 (0.55 to 74.25) | 0.19 | 3 (4122) | 2 (4688) | 0.80 |
| BRCA1 | 53.0, 37.0 | 38.46 (17.03 to 115.32) | 1.03 × 10−47 | 47.80 (20.76 to 145.03) | 1.87 × 10−46 | 219 (5944) | 4 (4686) | 0.60 |
| BRCA2 | 63.0, 40.0 | 8.19 (5.22 to 13.67) | 1.17 × 10−28 | 5.10 (3.12 to 8.83) | 2.89 × 10−12 | 193 (5969) | 18 (4672) | 0.14 |
| BRIP1 | 67.0, 46.0 | 2.05 (1.11 to 3.94) | 0.03 | 0.87 (0.41 to 1.93) | 0.73 | 30 (4805) | 14 (4676) | 0.04 |
| CHEK2 | 52.0, 42.0 | 1.62 (1.00 to 2.69) | 0.07 | 2.64 (1.48 to 4.79) | 2.36 × 10−3 | 45 (4923) | 24 (4287) | 0.79 |
| NBN | 64.5, 37.0 | 0.52 (0.15 to 1.54) | 0.27 | 0.45 (0.10 to 1.82) | 0.33 | 4 (4232) | 9 (4681) | 0.46 |
| PALB2 | 62.0, 39.0 | 2.06 (0.90 to 5.19) | 0.11 | 1.78 (0.61 to 5.59) | 0.33 | 16 (5004) | 7 (4683) | 0.50 |
| RAD51C | 61.0, 39.0 | 15.28 (3.97 to 137.01) | 6.29 × 10−06 | 12.09 (2.78 to 114.43) | 7.85 × 10−04 | 23 (4809) | 1 (4689) | 0.34 |
| RAD51D | 60.0, 32.5 | 7.99 (2.56 to 39.77) | 1.97 × 10−04 | 8.38 (2.17 to 47.23) | 2.51 × 10−03 | 20 (4809) | 2 (4688) | 0.44 |
aAge (in years) at time of ovarian cancer diagnosis
bAge (in years) at time of testing
cCorrected for False Discovery Rate
dAll genes were not tested for every sample
eComparing crude odds ratio to adjusted odds ratio
CI Confidence Interval, No. Number