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. 2019 Apr 11;12(2):55. doi: 10.3390/ph12020055

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© 2019 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Prodrugs can be used to improve oral bioavailability, by improving factors such as intestinal epithelial membrane permeability (1, ester prodrug) or solubility (50, phosphate prodrug) [125,126].