Table 1.
Potencies of tested inhibitors against fucose-specific lectins determined by a hemagglutination inhibition assay.
| AFL | RSL | AAL | AOL | PA-IIL | BC2L-C | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Inhibitor | Valency | Potency | β# | Potency | β# | Potency | β# | Potency | β# | Potency | β# | Potency | β# |
| l-fucose* | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Compound 1 | 3 | 64 | 21.3 | 512 | 170.7 | 32 | 10.7 | 64 | 21.3 | 16 | 5.3 | 8 | 2.7 |
| Compound 2 | 4 | 128 | 32 | 1024 | 256 | 128 | 32 | 256 | 64 | 32 | 8 | 16 | 4 |
| Compound 3 | 3 | 16 | 5.3 | 512 | 170.7 | 16 | 5.3 | 8 | 2.7 | 16 | 5.3 | 4 | 1.3 |
| Compound 4 | 4 | 16 | 4 | 256 | 64 | 16 | 4 | 8 | 2 | 16 | 4 | 4 | 1 |
| Compound 5 | 3 | 32 | 10.7 | 128 | 42.7 | 64 | 21.3 | 128 | 42.7 | 4 | 1.3 | 8 | 2.7 |
| Compound 11 | 1 | 4 | 4 | 8 | 8 | 4 | 4 | 4 | 4 | 4 | 4 | 1 | 1 |
| Compound 12 | 1 | 8 | 8 | 32 | 32 | 8 | 8 | 8 | 8 | 4 | 4 | 2 | 2 |
| Compound 13 | 1 | 4 | 4 | 8 | 8 | 4 | 4 | 4 | 4 | 4 | 4 | 2 | 2 |
| Compound 14 | 2 | 4 | 2 | 128 | 64 | 8 | 4 | 4 | 2 | 8 | 4 | 2 | 1 |
| Compound 15 | 1 | 0.125 | 0.125 | ND | - | ND | - | 0.5 | 0.5 | 0.5 | 0.5 | ND | - |
| Compound 16 | 1 | 0.125 | 0.125 | ND | - | ND | - | ND | - | 0.125 | 0.125 | 0.25 | 0.25 |
| Compound 17 | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 | ND | - |
| Compound 18 | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 1 | 0.5 | 0.5 | 0.03125 | 0.03125 | 0.5 | 0.5 |
| Compound 19 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 0.0625 | 0.0625 | 0.5 | 0.5 |
| Compound 20 | 2 | 0.5 | 0.25 | 2 | 1 | 1 | 0.5 | 1 | 0.5 | 0.125 | 0.0625 | 1 | 0.5 |
| Compound 21 | 1 | 2 | 2 | 4 | 4 | 2 | 2 | 4 | 4 | 4 | 4 | 4 | 4 |
| Compound 22 | 1 | 2 | 2 | 4 | 4 | 2 | 2 | 2 | 2 | 4 | 4 | 4 | 4 |
| Compound 23 | 2 | 8 | 4 | 8 | 4 | 4 | 2 | 8 | 4 | 4 | 2 | 8 | 4 |
* Standard # Potency/Valency ND Not detected.