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. 2019 May 24;7(2):44. doi: 10.3390/vaccines7020044

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cellular responses produced by combination vaccine in outbred CD-1 mice. (A) Vaccination schedule in outbred CD-1 mice. Mice were vaccinated with a combination of EBNA1vax, LMP1vax, and LMP2Avax three times at biweekly intervals, followed by harvesting of their splenocytes a week after the final vaccination. (B) Cellular responses to respective peptide pools, shown by IFNγ ELISPOT. (C) Plots showing CD4 or CD8 responses of CD-1 mice immunized with the triple vaccine or empty vector (pVax), stimulated with pooled peptides derived from EBNA1, LMP2A and LMP1. Cellular responses are driven by CD8+ cells, as shown by flow cytometry following stimulation of splenocytes.