Figure 7.

(A) Correlations between cellular/biochemical ratios (see Table 1 and Table 2) and lipophilicity determinations; HPLC-LogD (Left panel) and ALogP (Right panel). (B) α-Helical structure of ATSP-7041 showing it amphipathicity in terms of hydrophobic surface in blue (F³, W⁷, Cba¹⁰, hydrocarbon staple) that is interacting with Mdm2, whereas the hydrophilic surface in gray (T², E⁵, Q⁹, S¹²) is exposed to the solvent. The X-ray crystal structure of ATSP-7041 complexed with Mdmx (PDB code, 4N5T) was used for this analysis.