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. Author manuscript; available in PMC: 2019 Dec 28.
Published in final edited form as: Nat Genet. 2019 Jun 28;51(7):1123–1130. doi: 10.1038/s41588-019-0440-9

Figure 3 |. Mutations disrupting chromatin remodeling factors emerge throughout the progression to metastatic disease.

Figure 3 |

a–c, Exemplary phylogenetic trees in which BAP1 loss emerged early (a) and late (b,c). In cases with early loss, bi-allelic loss-of-function mutations reside on the trunks of the trees, whereas in cases where it arose later, at least one hit is situated on a branch. d, Dual immunostaining for BAP1 (brown) and melan-A (red) demonstrates that A13 and A29 metastases are null or BAP1 protein. e, Cases in which mutations in other chromatin remodeling factors were detected. These alterations tended to arise later, positioning them on the branches.