Skip to main content
. Author manuscript; available in PMC: 2019 Dec 28.
Published in final edited form as: Nat Genet. 2019 Jun 28;51(7):1123–1130. doi: 10.1038/s41588-019-0440-9

Figure 6 |. The evolution of metastatic uveal melanoma.

Figure 6 |

‘CNA’, copy number alteration. ‘Other CNAs’ include combinations of 16q loss, 8p loss, 6q loss, or 6p gain, among others. ‘Additional pathogenic mutations’ include various combinations of 8q amplification, 1q gain, CDKN2A loss, SWI/SNF mutations, and EZH2 mutations, among others. The precursors to primary uveal melanoma are not well understood, as reflected here by the questions marks adjacent to those clinical stages in our model.