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. 2019 Jul 15;17:43. doi: 10.1186/s12969-019-0350-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Screen failure and CTP selection reasons. Reasons for screen failures: There was a total of 23 screen failures, with 12 patients not meeting inclusion or meeting exclusion criteria, and 11 not consented for other reasons. “Not feasible” refers to family not consenting because of visit schedule or travel time required to reach to study site. Reasons for choice of CTP: The number of patients treated with each of the CTPs is shown in bold text below the CTP. The physician and patient/family jointly decided upon which CTP to use, and could choose more than one reason for their selection. The reasons for CTP selection are listed, and in the same row the corresponding number (%) of patients enrolled for each reason within each of the three CTPs is shown. Not shown are concerns about patient compliance (n = 1, CTP B, 4%), or insurance issues (n = 0). CTP: consensus treatment plan; IV CS: intravenous corticosteroid (methylprednisolone); jLS: juvenile localized scleroderma; mo: month; MTX: methotrexate; n: number of patients; rx: treatment; PO CS: oral corticosteroid (prednisone or prednisolone)