Figure 1.

VSD imaging reveals spontaneous fluctuations of cortical activity are regionally heterogeneous and bilaterally synchronous in wild-type but not acallosal I/LnJ mice. A, Schematic showing mouse cortical regions imaged. Secondary motor cortex is removed in left hemisphere to show anterior cingulate (beneath it), found in the medial wall of the cortex in the longitudinal fissure. Note that signals from these two regions cannot be separately resolved. B, Example traces showing VSD signal from selected regions in wild-type (WT) and acallosal I/LnJ mice. C, Montages showing VSD signal from entire imaging field. i–iv correspond to grayed regions of traces in B. D, Matrices showing pairwise correlation coefficients for interhemispheric regions (shown in A) in wild-type and acallosal I/LnJ mice. BC, C2 primary barrel cortex; CG, cingulate cortex; FL and S1FL, forelimb primary somatosensory cortex; HL and S1HL, hindlimb primary somatosensory cortex; M1, primary motor cortex; M2_A, anterior cingulate (dorsal part) and anterior segment of secondary motor cortex; M2p, anterior cingulate (dorsal and ventral part) and posterior segment of secondary motor cortex; ptA, parietal association cortex; RS, retrosplenial cortex; S1BC, primary somatosensory barrel cortex; V1, primary visual cortex; V2, secondary visual cortex; V2LM, lateromedial secondary visual cortex; V2MM, mediomedial secondary visual cortex; L, left; R, right. The brain is oriented so that the anterior direction is up and both hemispheres are shown.