Figure 4.

Specific enzymes of the ganglioside biosynthetic pathway are downregulated in striatum and cortex of YAC128 mice. A, Simplified scheme of the ganglioside biosynthetic pathway. Critical enzymes in the pathway are indicated in red. Gangliosides of the asialo-series and of the c-series are less abundant and were omitted to improve clarity. B, Analysis of gene expression in YAC128 mice by real-time PCR. Each dot represents an individual animal. From five to six animals were used in the analysis. Lines indicate the mean value in each group. Data are expressed as ratios of HD to wild type. *p < 0.05; **p < 0.001; ***p < 0.0001.