Figure 1.
The influence of the glial toxin MSO (0.1 mm) on frequency increases evoked by ATP and SP in rhythmic medullary slice preparations. Local application of ATP (0.1 mm, 10 s, A) and SP (1 μm, 10 s, C) in the preBötC during control conditions (left panels) and in the presence of MSO and GLN (1.5 mm, middle panels). Group data (n = 7) for the changes in frequency associated with ATP (B) and SP (D) applications. *p < 0.001, significant difference from baseline or GLN/MSO baseline; #p < 0.001, significant difference between ATP responses.