Colocalization of HRD1 and APP in the brain and neuronal cells. a, Colocalization of HRD1 and APP in the murine hippocampus and cerebral cortex. The coronal sections of the murine hippocampus (top and middle) and cerebral cortex (bottom) were subjected to immunofluorescence staining with HRD1 (Abgent), APP (6E10), and NeuN antibodies. DG, dentate gyrus; Cortex, cerebral cortex. Scale bars, 200 μm. b, Colocalization of HRD1 and APP in the ER. SH-SY5Y cells were subjected to immunofluorescence staining with HRD1 (Otsuka), APP (C-terminal), and PDI antibodies. Scale bars, 20 μm.