Figure 4.

Intrinsic membrane properties of Clcn2^−/− pyramidal neurons are altered. A, Sample traces of current-clamp recordings. Inset shows the current step protocol, and the same colors indicate same injected currents: dark blue, −100 pA; green, −50 pA; red, 0 pA; light blue, 25 pA; magenta, 50 pA; yellow, 75 pA. Calibration (for inset): 250 ms, 25 pA. B, Comparison of input resistance (left), AP threshold (middle), and number of APs generated at various current injections (right). Filled symbols represent WT, and open symbols represent KO. Error bars represent SEM in all graphs.